zhaoyf.jpg (33770 bytes)赵玉芬院士




性别：女
技术职称：院士, 教授
Email：zhaoyf@chem.tsinghua.edu.cn

学历:

1971年毕业于台湾新竹清华大学,

1975年在美国纽约州立大学石溪分校化学系获得博士学位,

1975-1979年分别在美国纽约州立大学石溪分校和美国纽约大学化学系从事博士后研究;

1979年回国, 在中国科学院化学研究所工作．为清华大学化学系教授，任清华大学生命科学与工程研究院副院长和清华大学生命有机磷化学教育部重点实验室主任.

2000年到厦门大学化学化工学院工作。

主要研究领域：

生命有机磷化学、生物有机化学、有机合成化学,生命起源

研究成果：

    1. 药物化学：发明了合成抗癌药三尖杉酯碱母核的新方法。开发了一系列无毒的抗血吸虫新化合物。
    2. RNA及DNA的切割剂：发现了磷酰化组氨酸的饱和溶液可以切割RNA及DNA；切割机理是与生物化学中水解磷酸二酯键一样，正与美国俄亥俄大学合作核酸定点切割试剂的研究。
    3. N－磷酰氨基酸自催化作用：N－磷酰氨基酸可以自身组装成多肽，并将核苷磷酰化为核苷酸。因此，N－磷酰氨基酸可以在一锅反应中同时生成肽库；核酸库，及肽－核酸复合库。
    4. 生命起源：磷酰氨基酸能同时生成核酸及蛋白，又能生成LB－膜及脂质体。因此，它是生命进化的最小系统。

作为课题负责人,负责完成多项国家自然科学基金重点项目,杰出青年基金,国家教委优秀人才基金等科研项目.曾获中科院科技进步二等奖, 三等奖, 首届中国青年科学家奖，国家教委科技进步二等奖2 项在国际、国内刊物上发表高水平论文近200篇.

社会兼职： 全国政协委员，全国青联副主席

代表性论文目录:
  1. Xin Chen, Nan-Jiang Zhang and Yu-Fen Zhao, Bioorganic Chemistry, 1997, 25, 23-31, “Reaction Kinetics of Oxyphosphoranes with Model Compounds of Nucleosides”
  2. Yan-Mei Li, Ming Wei, Yu-Fen Zhao, Jian-Yuan Yu, Qun Zhou, Spectroscopy Letters, 1999, 32(2), 197-203, “Investigations on the Effects of cAMP on Membrane Phospholipid of Human Erythrocytes by Laser Raman Spectroscopy”
  3. Yu-Fen Zhao, Yong Ju, Yan-Mei Li Qian Wang, Yin-Wu Yin, Bo Tan, Int. J. Of Peptide and Protein Res., 1995, 1-5, 514-518, “Self-Activation of N-Phosphoamino Acids and N-Phosphodipeptides in Oligopeptide Formation”
  4. Yu-Fen Zhao, Qing-Jin Yan, Qian Wang, Int. J. Of Peptide and Protein Res., 1996, 46, 276-281. “Phosphoryl Transfer Reaction Regulated by Amino Acid Side Chains: A Model for Phosphorproteins”
  5. Yong-Fang Li, Yao-Wu Sha, Yuan Ma, Yu-Fen Zhao, Biochemical Biophysical Research Communication, 1995, 213(3), 875-880, “Cleavage of DNA by N-Phosphoryl Histidine”
  6. Yu-Fen Zhao and Pei-Sheng Cao, J. Chela-Flores and F. Raulin (eds.), Chemical Evolution: Physics of the Origin and Life, 1996, 279-285, Kluwer Academic Publishers, Printed in the Netherland, “Basic Models of Chemical Evolution of Life: The Minimum Evolving System”
  7. Wei-Hua Zhou, Yong Ju, Yu-Fen Zhao, Qing-Gang Wang and Guo-an Luo, Origins of Life and Evolution of the Biosphere, 1996, 26, 547-560, “Simultaneous Fomation of Peptides and Nucleotides from N-Phosphothreonine”
  8. Hua Fu, Zhao-Long Li, Yu-Fen Zhao, Guang-Zhong Tu, J. Am. Chem. Soc., 1999, 121, 291-295, “Oligomerization of N,O-Bis(trimethylsilyl)-? -amino Acids into Peptides Mediated by o-Phenylene Phosphorochloridate”
  9. Nan-Jing Zhang, Hai-Yan Lu, Xin Chen, Yu-Fen Zhao, Synthesis, 1998, 376-378, “A Facile Synthesis of Acylaminotetraoxyspirophosphoranes”
  10. Hua Fu, Guang-Zhong Tu, Zhao-Long Li, Yu-Fen Zhao, Synthesis, 1998, 855-858, “Synthesis of 2-Phenoxy-2,75-spirol[1,3,2-benzodioxaphosphole-2,2’-1,3,2-oxazophospholan]-5’-ones”

　

　

Yu-Fen Zhao Ph.D

Professor.of Chemistry

Academician of Chinese Academy Science.

  1. 1971 B.S., National Tsinghua University in Taiwan

  2. 1975 Ph.D., State University of New York at Stony Brook,

    Advisor: Prof. Fausto Ramirez.

  3. 1975-1979 Postdoctoral Associate,

    State University of New York at Stony Brook and New York University,

  4. 1979-1988 Associate Professor, Professor,

    Institute of Chemistry Academia Sinica, Beijing

  5. 1988-2000 Present Professor,

    Department of Chemistry, Tsinghua University, Beijing

  6. 2000- Present Professor,

    Department of Chemistry, Xiamen University, Xiamen

  7. 1993-present Director, Bioorganic Phosphorus Chemistry Laboratrory.

  8. 1994-present Vice-Dean, School of Life Science & Engineering,Tsinghua University, Beijing

  9. 1991 was elected as the youngest Member of Chinese Academy of Sciences, councilor of the Chinese Chemical Society, Full Member of the Academy of Creative Endeavors of Russia

    Research: Field: Organic Phosphorus Chemistry , Bioorganic Chemistry, Origin of Life, Medicinal Chemistry.

Achievement:

1. Medicine chemistry

Invented a new method to synthesize the skeleton of the Celphalatoxine,which is an anti-cancer reagent. Developed a new type of non-toxic compounds, which are highly effective for curing theschistosomiasis.

2. RNA and DNA cleavage reagents

Discovered that the N-phospho-histidine could cleave RNA and DNA by hydrolysis on the phospho-diester bond, Also found that N-phospho-serine in histidine could cleave DNA and RNA by a bio-mimic mechanism Cooperated with Ohio University for site specific cleavage of RNA and DNA.

3. Auto-catalysis of the N-phospho-amino acids:

It was found that N-phospho-amino acids could not only self-assemble into oligo-peptides in organic and aqueous condition from pH 2 to 9, at the temperature 0-80oC, but also phosphorylate the nucleosides into nucleotides and oligo-nucleotides. Therefore, N-phospho-amino acids could produce the peptide library,nucleotide library and the peptide-nucleotide conjugated library in one pot reaction.4. Origin of LifeN-phospho-amino acids also could form the LB-membrane and lipsome structure, together with auto-catalysis for peptide and nucleotides formation, it was proposed as the minimum evolved system.
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